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[Download] "Actin Polymerization in Apicomplexan" by Avinash Kale # eBook PDF Kindle ePub Free

Actin Polymerization in Apicomplexan

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eBook details

  • Title: Actin Polymerization in Apicomplexan
  • Author : Avinash Kale
  • Release Date : January 13, 2019
  • Genre: Medical,Books,Professional & Technical,Sports & Outdoors,Science & Nature,Life Sciences,
  • Pages : * pages
  • Size : 10414 KB

Description

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.
The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria.  As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.
Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.


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